Debut is a San Diego based company leading the biomanufacturing revolution for a cleaner and healthier world. Our platform technology development focuses on researching and producing the next generation of natural ingredients and functional molecules. We offer a fast-paced, exciting environment where our people contribute at all levels toward the company’s success.
As a Senior Scientist in Metabolic Engineering your focus will be on pathway optimization and strain improvement ensuring completion of projects with strict time deadlines. You will help lead a team of seven scientists to meet the needs of Debut’s strain engineering and your responsibilities will include:
- Engineering metabolic pathways and performing genomic editing using CRISPR/Cas9 systems
- Developing medium-to-high throughput strain construction to rapidly improve bioproduction of target molecules
- Designing, setting up, executing, and documenting metabolic engineering experiments. Working with peers and management to define pertinent experiments, develop protocols, collect, and analyze resultant data within agreed timelines
- Coaching junior staff and problem solving with them to ensure progress across multiple deadlines
- Writing Standard Operating Procedures (SOPs) for internal use
- Project management and tracking strain building and testing
- Collaborating with fermentation and product purification processes to ensure work products are delivered on time and at spec
- Functioning as the point person for a project and processing data for subsequent review and reporting.
- Managing the strain engineering workflow and ensuring on time delivery
Qualifications
- PhD with 8+ years of experience in metabolic engineering, synthetic biology, or a related field
- Proficient and thoughtful in designing and performing CRISPR-based genomic editing
- Deep knowledge in the central metabolism of E. coli and optimization of metabolic pathways
- Must have experience with metabolic engineering in E. coli with a proven track record of creating commercial strains
- Experience working with other organisms is highly desirable
- Strong analytical and problem-solving abilities with a proven track record of being innovative and generating key breakthroughs to advance cell lines.
- Has lead campaigns from conception to pilot production for small molecules
- Experienced in BLAST search, sequence alignment, and phylogenetic trees
- Familiar with Geneious, MindManger, and Smartsheet
- Must possess excellent communication and interpersonal skills to facilitate interactions with a highly interdisciplinary team
- Motivated by a sense of urgency, attention to detail, and an engrained penchant for professional development of themselves and their co-workers
- Strong organizational and time-management skills including managing projects simultaneously
- Excellent attention to details and diligent adherence to deadlines and deliverables
- Ability to prioritize responsibilities and multi-task
- Must be motivated, self-directed, and work well with little oversight
- Ability to learn quickly in a fast-paced startup environment
- Must be willing to work non-standard hours supporting a 24/7 operation including weekends
To learn more about Debut please see:
DSM Agrees to Evaluate Debut’s Scalable Cell-Free Manufacturing Platform (Genetic Engineering & Biotechnology News): https://www.genengnews.com/topics/bioprocessing/dsm-agrees-to-evaluate-debut-biotechs-scalable-cell-free-manufacturing-platform/
Next gen cell-free biomanufacturing could unlock opportunities to synthesize natural ingredients (Food Navigator-USA): https://www.foodnavigator-usa.com/Article/2021/03/23/Next-gen-cell-free-biomanufacturing-could-unlock-opportunities-to-biosynthesize-far-wider-set-of-natural-ingredients-claims-startup
Debut Biotech Awarded $1M from Air Force Research Lab for aerospace applications of cell-free biomanufacturing (PRWeb): https://www.prweb.com/releases/debut_biotechnology_awarded_1m_from_air_force_research_lab_to_leverage_cell_free_continuous_biomanufacturing_in_aerospace_applications/prweb17394934.htm
Our website: https://debutbiotech.com